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Novel unsaturated purine nucleosides

โœ Scribed by Vasu Nair; Lyons Arthur G

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
529 KB
Volume
45
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

The synthesis of a number of novel purine ribonucleosides bearing one degree of unsaturation at the P-position is described.

The two key reactions used in the synthesis of these compounds is a palladium-catalyzed cross-coupling reaction and an ozonolysis. These synthetic transformations have rarely been used in nucleoside chemistry.

Isomerixation of an allylpurine system to a vinylpurine system under the conditions of the cross-coupling reaction and also under fluoride ion catalysis is discussed. The novel 2-formylpurine nucleosides described appear to be easily hydrated.

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## Abstract The biochemical features of two families with purine nucleoside phosphorylase deficiency are compared. Laboratory studies and an evaluation of kinetic and physical properties of erythrocyte purine nucleoside phosphorylase give evidence that a) the degree of abnormality in uric acid and