✦ LIBER ✦

Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

✍ Scribed by Scott H. Watterson; Charles M. Langevine; Katy Van Kirk; James Kempson; Junquing Guo; Steven H. Spergel; Jagabandhu Das; Robert V. Moquin; Alaric J. Dyckman; David Nirschl; Kurt Gregor; Mark A. Pattoli; XiaoXia Yang; Kim W. McIntyre; Guchen Yang; Michael A. Galella; Hollie Booth-Lute; Laishun Chen; Zheng Yang; David Wang-Iverson; Murray McKinnon; John H. Dodd; Joel C. Barrish; James R. Burke; William J. Pitts

Book ID: 113496234
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 933 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2011.09.111

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Novel Tricyclic Inh

ChemInform Abstract: Novel Tricyclic Inhibitors of IKK2: Discovery and SAR Leading to the Identification of 2-Methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo [4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).

✍ Scott H. Watterson; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 21 KB

ChemInform Abstract: Discovery and Precl

ChemInform Abstract: Discovery and Preclinical Studies of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo [2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo Active Potent VEGFR-2 Inhibitor.

✍ Rejean Ruel; et al. et al. 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 20 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Acridone-Based Inhibitors of Inosine 5‘-

Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase: Discovery and SAR Leading to the Identification of N -(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

✍ Watterson, Scott H.; Chen, Ping; Zhao, Yufen; Gu, Henry H.; Dhar, T. G. Murali; 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 206 KB

Improved Synthesis of the Selective Rho-

Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro- N 4-{3,5-difluoro-4-[(3-methyl-1 H -pyrrolo[2,3- b ]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine

✍ Schirok, Hartmut; Paulsen, Holger; Kroh, Walter; Chen, Gang; Gao, Ping 📂 Article 📅 2010 🏛 American Chemical Society 🌐 English ⚖ 419 KB

Discovery of N-[2-[5-[Amino(imino)methyl

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa1

✍ Phillips, Gary B.; Buckman, Brad O.; Davey, David D.; Eagen, Keith A.; Guilford, 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 178 KB

ChemInform Abstract: Discovery of N-[2-[

ChemInform Abstract: Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro-6- [3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl] -N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa.

✍ M. M. MORRISSEY; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views