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Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro- N 4-{3,5-difluoro-4-[(3-methyl-1 H -pyrrolo[2,3- b ]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine

✍ Scribed by Schirok, Hartmut; Paulsen, Holger; Kroh, Walter; Chen, Gang; Gao, Ping


Book ID
118015749
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
419 KB
Volume
14
Category
Article
ISSN
1083-6160

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2-[2-Chloro-4-fluoro-5-(1,3,4,5,6,7-hexa
✍ Ling, Yong ;Xu, Hao ;Yao, Cheng πŸ“‚ Article πŸ“… 2006 πŸ› International Union of Crystallography 🌐 English βš– 299 KB

In the molecule of the title compound, C 23 H 20 ClFN 2 O 4 , the cyclohexene ring is not planar and has a flattened boat conformation. Intermolecular C-HÁ Á ÁO hydrogen bonds, linking the independent molecules into dimers, may be effective in the stabilization of the crystal structure.