Novel transformations of penicillins into 2-azetidinones with diazo- and azido-compounds and a novel synthesis of desacetoxycephalosporin
โ Scribed by Mitsuo Numata; Yoshio Imashiro; Isao Minamida; Masayoshi Yamaoka
- Book ID
- 108384494
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 158 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
The regioselective nitroso Diels-Alder (NDA) cycloadditions of 3-dienyl-2-azetidinones with nitrosobenzene to generate oxazine-substituted b-lactams in excellent yields are reported. The amidiolytic ring opening of the cycloadducts with sodium methoxide followed by iodocyclization using I 2 /K 2 CO
A Novel Asymmetric Synthesis of 2-Azetidinones from Achiral Precursors. -Cyclocondensation of chloride (I) with p-methoxybenzylamine in the presence of stoichiometric amounts of a chiral salen-copper(II) is investigated. The desired azetidinone (III) is obtained with considerable enantioselectivity