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A novel synthesis and transformations of isothiochroman 2,2-dioxide

โœ Scribed by Olena O. Shyshkina; Tetyana M. Tkachuk; Tetiana A. Volovnenko; Yulian M. Volovenko; Roman I. Zubatyuk; Volodymyr V. Medviediev; Oleg V. Shishkin

Book ID
113930969
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
780 KB
Volume
53
Category
Article
ISSN
0040-4039

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Synthesis of isothiochroman 2,2-dioxide
Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors
โœ Christophe Peixoto; Patrick Laurin; Michel Klich; Claudine Dupuis-Hamelin; Pasca ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 168 KB

The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory pot