Novel Technologies for Vaccine Development

✍ Scribed by Igor S Lukashevich, Haval Shirwan (eds.)

Publisher: Springer-Verlag Wien
Year: 2014
Tongue: English
Leaves: 393
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

✦ Table of Contents

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Reverse Genetics Approaches for Rational Design of Inactivated and Live Attenuated Influenza Vaccines....Pages 3-32
Viral-Vectored Vaccines to Control Pathogenic Filoviruses....Pages 33-60
Alphavirus Replicon Vectors for Prophylactic Applications and Cancer Intervention....Pages 61-85
Current Status and Future of Polio Vaccines and Vaccination....Pages 87-112
Current Status of Hantavirus Vaccines Development....Pages 113-151
Experimental DNA-Launched Live-Attenuated Vaccines Against Infections Caused by Flavi- and Alphaviruses....Pages 153-177
Sugar-Based Immune Adjuvants for Use in Recombinant, Viral Vector, DNA and Other Styles of Vaccines....Pages 179-200
Front Matter....Pages 201-201
Adenovirus-Based Vectors for the Development of Prophylactic and Therapeutic Vaccines....Pages 203-271
Radiovirotherapy for the Treatment of Cancer....Pages 273-290
TRICOM Poxviral-Based Vaccines for the Treatment of Cancer....Pages 291-327
The Use of Oncolytic Herpesvirus for the Treatment of Cancer....Pages 329-345
SA-4-1BBL: A Novel Form of the 4-1BB Costimulatory Ligand as an Adjuvant Platform for the Development of Subunit Cancer Vaccines....Pages 347-386

✦ Subjects

Vaccine; Pharmaceutical Sciences/Technology; Immunology

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