Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines

✍ Scribed by Mark A. Tomai, John P. Vasilakos (auth.), Manmohan Singh (eds.)

• Publisher: Springer US
• Year: 2013
• Tongue: English
• Leaves: 368
• Edition: 1
• Category: Library

✦ Synopsis

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

✦ Table of Contents

Front Matter....Pages i-x
Front Matter....Pages 1-1
TLR7/8 Agonists as Vaccine Adjuvants....Pages 3-18
Preclinical and Clinical Development of Synthetic i NKT-Cell Glycolipid Agonists as Vaccine Adjuvants....Pages 19-64
Mucosal Vaccination: Opportunities and Challenges....Pages 65-80
Oral Vaccination: Attenuated and Gene-Based....Pages 81-104
Front Matter....Pages 105-105
Development of Biophysical Assays to Better Understand Adjuvanted Vaccine Formulation Potency and Stability....Pages 107-118
High Throughput Screening for Stabilizers of Vaccine Antigens....Pages 119-143
Exploring Novel Analytical Tools to Improve Characterization of Vaccine Formulations....Pages 145-159
Immunobioengineering Approaches Towards Combinatorial Delivery of Immune-Modulators and Antigens....Pages 161-181
Front Matter....Pages 183-183
Current Status of Electroporation Technologies for Vaccine Delivery....Pages 185-215
Microneedles for Intradermal Vaccination: Immunopotentiation and Formulation Aspects....Pages 217-232
MicroCor ® Transdermal Delivery System: A Safe, Efficient, and Convenient Transdermal System for Vaccine Administration....Pages 233-244
Mimopath™-Based Vaccine Delivery....Pages 245-265
Front Matter....Pages 267-267
NanoBio™ Nanoemulsion for Mucosal Vaccine Delivery....Pages 269-286
Influenza Virosomes as Antigen Delivery System....Pages 287-307
Matrix M Adjuvant Technology....Pages 309-320
Front Matter....Pages 321-321
Strategies for the Nonclinical Safety Assessment of Vaccines....Pages 323-349
Safety Challenges Facing Next Generation Vaccines and the Role for Biomarkers....Pages 351-364
Back Matter....Pages 365-369

✦ Subjects

Immunology; Medical Microbiology; Vaccine; Pharmaceutical Sciences/Technology