Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites.
Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include:
- challenges in delivery of biopharmaceuticals
- novel formulation approaches for peptide and protein injectables
- non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs
- immune response, adjuvants and delivery systems for vaccines
- several examples of delivery systems forย different biopharmaceuticals
- a critical assessment of delivery technologies for biopharmaceuticalsย
Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.Content:
Chapter 1 Challenges in Delivery of Biopharmaceuticals; the Need for Advanced Delivery Systems (pages 1โ8): Hanne Morck Nielsen and Lene Jorgensen
Chapter 2 Novel Formulation Approaches for Peptide and Protein Injectables (pages 9โ28): Mingshi Yang and Sven Frokjaer
Chapter 3 Novel Non?Injectable Formulation Approaches of Peptides and Proteins (pages 29โ67): Shirui Mao, Dongmei Cun and Yoshiaki Kawashima
Chapter 4 Chemical Vectors for Delivery of Nucleic Acid?Based Drugs (pages 69โ92): Elizabeth A. Vasievich and Leaf Huang
Chapter 5 Viral Technology for Delivery of Nucleic Acids (pages 93โ112): Shervin Bahrami and Finn Skou Pedersen
Chapter 6 The Innate Immune Responses, Adjuvants and Delivery Systems (pages 113โ127): S. Moein Moghimi
Chapter 7 Lipid Nanoparticle?Based Systems for Delivery of Biomacromolecule Therapeutics (pages 129โ148): Susana Martins, Domingos C. Ferreira and Eliana B. Souto
Chapter 8 Dendrimers in Delivery of Biopharmaceuticals (pages 149โ168): Chandan Thomas and Fakhrul Ahsan
Chapter 9 Modification of Peptides and Proteins (pages 169โ191): Susanne Hostrup, Kasper Huus and Henrik Parshad
Chapter 10 Nanocarriers for the Delivery of Peptides and Proteins (pages 193โ205): Kenneth Lundstrom
Chapter 11 Polymer?Based Delivery Systems for Oral Delivery of Peptides and Proteins (pages 207โ226): Bruno Sarmento, Domingos Ferreira and Teofilo Vasconcelos
Chapter 12 Advanced Pulmonary Delivery of Peptides or Proteins Using Polymeric Particles (pages 227โ244): Yu Seok Youn, Kang Choon Lee, You Han Bae, Kun Na and Eun Seong Lee
Chapter 13 Polymer Microparticles for Nucleic Acid Delivery (pages 245โ267): Tim Pearce, Jared Hierman and Chun Wang
Chapter 14 Pulmonary Delivery of Small Interfering RNA for Novel Therapeutics (pages 269โ289): Qing Ge, David Evans, John J. Xu, Harry H. Yang and Patrick Y. Lu
Chapter 15 Lipid?Based Formulations for siRNA Delivery (pages 291โ304): Camilla Foged, Pieter Vader and Raymond M. Schiffelers
Chapter 16 Cellular Bioavailability of Peptide Nucleic Acids (PNAs) Conjugated to Cell Penetrating Peptides (pages 305โ338): Takehiko Shiraishi and Peter E. Nielsen
Chapter 17 DEAE?dextran?MMA Graft Copolymer for Non?Viral Delivery of DNA (pages 339โ355): Yasuhiko Onishi, Yuki Eshita and Masaaki Mizuno
Chapter 18 Liposomes in Adjuvant Systems for Parenteral Delivery of Vaccines (pages 357โ376): Dennis Christensen, Karen Korsholm, Grith Kroyer Wood, Afzal Mohammed, Vincent Bramwell, Peter Andersen, Else Marie Agger and Yvonne Perrie
Chapter 19 Influenza Virosomes as Delivery Systems for Antigens (pages 377โ393): Mario Amacker, Stefan Moese, Andreas R. Kammer, Ari Helenius and Rinaldo Zurbriggen
Chapter 20 GRAZAXยฎ: An Oromucosal Vaccine for Treating Grass Pollen Allergy with Immunotherapy (pages 395โ404): Annette Rommelmayer Lundegaard, Lise Lund and Jorgen Nedergaard Larsen
Chapter 21 Delivery Technologies for Biopharmaceuticals: A Critical Assessment (pages 405โ412): Marco van de Weert