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Novel Synthetic Approach to 6,7-Dihydro-5 H -imidazo[1,5-a]-pyrazin-8-ones

✍ Scribed by Gopalsamy, Ariamala; Shi, Mengxiao

Book ID
121500790
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
62 KB
Volume
5
Category
Article
ISSN
1523-7060

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## Abstract A new method was developed for the synthesis of 6,7‐dihydro‐5__H__‐pyrimido[4,5‐__e__][1,4]diazepin‐8(9__H__)‐one derivatives. The key to construct the pyrimido[4,5‐__e__][1,4]diazepine core is the intramolecular amidation of __N__‐((4‐amino‐6‐chloropyrimidin‐5‐yl)methyl)‐substituted am