NOVEL SYNTHESIS OF POLYFUNCTIONALISED BIARYL, PYRIDAZINE, AND PHTHALAZINE DERIVATIVES
โ Scribed by Barsy, Magda A.; El Latif, Fawi A.; El Rady, Eman A.; Hassan, Mohamed E.; El Maghraby, Mohamed A.
- Book ID
- 120161655
- Publisher
- Taylor and Francis Group
- Year
- 2001
- Tongue
- English
- Weight
- 276 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0039-7911
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## Abstract magnified image Fifteen new pyridazine and phthalazine derivatives were prepared (in good to excellent yields) and tested __in vitro__ as antimicrobial compounds. All the compounds have proved to have a remarkable activity against __Gram positive__ germs, the results on __Sarciria Lute
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ethyl 2-arylhydrazono-3-butyrates 2 reacted with 2-cyano-N-(4-methylphenyl) acetamide 1a and 2cyano-N-(thiazol-2-yl)acetamide 1b to give the pyridinedione, 4 and pyridazine 5 derivatives in 3:1 ratio. The products 4 and 5 have been transformed into different phthalazine, pyrimido[4,5-c]pyridazine, p