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Pyridazine and phthalazine derivatives with potential antimicrobial activity

✍ Scribed by Roxana M. Butnariu; Maria D. Caprosu; Vasilichia Bejan; Ionel I. Mangalagiu; Margareta Ungureanu; Antonia Poiata; Cristina Tuchilus; Margareta Florescu

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
302 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Fifteen new pyridazine and phthalazine derivatives were prepared (in good to excellent yields) and tested in vitro as antimicrobial compounds. All the compounds have proved to have a remarkable activity against Gram positive germs, the results on Sarciria Luteea being spectacular. Correlation structure ‐ biological activity have been done. Stereo‐ and region‐ chemistry involved in these reactions are discussed.

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