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Studies with 2-(acetonylthio)benzothiazole: Novel synthesis of pyridazin-6(1H)-one, pyridazin-6(1H)-imine, and phthalazine derivatives of antimicrobial and antifungal activities

✍ Scribed by Fatima A. Al-Omran; Adel A. El-Khair

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
143 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A novel series of (Z)‐1‐(arylhydrazono)‐1‐(benzothiazol‐2′‐ylthio)propan‐2‐ones have been prepared and their utility as building blocks in the synthesis of novel derivatives of Pyridazin‐6(1__H__)‐ones, pyridazin‐6(1__H__)‐imines, and phthalazine incorporating a benzothiazole residue are investigated. All of the title compounds were confirmed by elemental analysis, IR, ^1^H NMR, ^13^C NMR, NOE, and mass spectrometry. The synthesized compounds are screened for their antibacterial as well as antifungal activity. All the tested compounds showed high to moderate activity against the selected microorganisms. J. Heterocyclic Chem., (2011).

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