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A convenient and facile synthesis of pyridine, pyridazine, pyrimido-[4,5-c]pyridazine, pyrido[3,4-c]pyridazine, 1,6-naphthyridine and phthalazine derivatives

✍ Scribed by Eman A. El Rady; Magda A. Barsy

Publisher: Journal of Heterocyclic Chemistry
Year: 2006
Tongue: English
Weight: 450 KB
Volume: 43
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570430201

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✦ Synopsis

Ethyl 2-arylhydrazono-3-butyrates 2 reacted with 2-cyano-N-(4-methylphenyl) acetamide 1a and 2cyano-N-(thiazol-2-yl)acetamide 1b to give the pyridinedione, 4 and pyridazine 5 derivatives in 3:1 ratio. The products 4 and 5 have been transformed into different phthalazine, pyrimido[4,5-c]pyridazine, pyrido[3,4-c]pyridazine and 1,6-naphthyridine derivatives. The chemical structures have been confirmed by analytical and spectral analysis.

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