Novel synthesis of 4,5,7,8-tetrahydro-6H-imidazo[4,5-e]-[1,4]diazepine-5,8-dione. A cyclic xanthine homolog
✍ Scribed by É. I. Ivanov; G. D. Kalayanov
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 105 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0009-3122
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## Abstract A new method was developed for the synthesis of 6,7‐dihydro‐5__H__‐pyrimido[4,5‐__e__][1,4]diazepin‐8(9__H__)‐one derivatives. The key to construct the pyrimido[4,5‐__e__][1,4]diazepine core is the intramolecular amidation of __N__‐((4‐amino‐6‐chloropyrimidin‐5‐yl)methyl)‐substituted am
## Abstract magnified image A series of tricyclic 7,8,10,11‐tetrahydro‐5__H__‐benzo[__e__]pyrimido[4,5‐__b__][1,4]diazepin‐9(6__H__)‐ones were prepared in moderate to high yields using TFA‐promoted iminium‐cyclization reactions of 3‐(6‐(butylamino)‐4‐chloropyrimidin‐5‐ylamino)cyclohex‐2‐enones and