Novel Synthesis and Reactions of 5,7-Dialkyl-4,6-dioxo-4,5,6,7-tetrahydro- isothiazolo[3,4,- d ]pyrimidine-3-carbonitriles and 6-Methyl-4-oxo-4 H -1-aza-5-oxa-2- thiaindene-3-carbonitrile
✍ Scribed by Chang, Yong-Goo; Cho, Hyong Soon; Kim, Kyongtae
- Book ID
- 120710006
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 101 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1523-7060
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## Abstract A facile synthesis of __trans__ isomers of 4‐aryl‐3‐methyl‐6‐oxo‐4,5,6,7‐tetrahydro**‐**2__H__**‐**pyrazolo[3,4‐__b__]pyridine‐5‐carbonitriles via three‐component condensation reaction of an aldehyde, 3‐amino‐5‐methylpyrazole and ethyl cyanoacetate in acetonitrile has been developed und
The title compound, C 20 H 15 FN 4 O, was synthesized by the reaction of 5-amino-3-methyl-1-phenylpyrazole with ethyl 2cyano-3-(4-fluorophenyl)-1-acylate in glycol under microwave irradiation. The tetrahydropyridine ring adopts a distorted envelope conformation. The pyrazole ring forms a dihedral an
## Abstract All products are purified by recrystallization from ethanol.