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Novel Syntheses of 2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde: A Key Intermediate for the Synthesis of the Angiotensin II Antagonist Losartan

✍ Scribed by Griffiths, Gareth J.; Hauck, Michael B.; Imwinkelried, René; Kohr, Jörg; Roten, Conrad A.; Stucky, Gerhard C.; Gosteli, Jacques


Book ID
111893514
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
187 KB
Volume
64
Category
Article
ISSN
0022-3263

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2-Butyl-5-chloro-3H-imidazole-4-carbalde
✍ S. L. Gaonkar; K. M. Lokanatha Rai 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 81 KB 👁 1 views

## Abstract magnified image The title compound 2‐butyl‐5‐chloro‐3__H__‐imidazole‐4‐carbaldehyde was transformed into tricyclic heterocycles by substituting the chlorine atom by an unsaturated thiolate or alkoxide and then converting aldehyde function into 1,3‐dipole. Chloramine‐T was used as an ef