✦ LIBER ✦

2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde as a new synthon for the synthesis of fused ring heterocycles via intramolecular 1,3-dipolar cycloaddition reactions

✍ Scribed by S. L. Gaonkar; K. M. Lokanatha Rai

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 81 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.250

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

The title compound 2‐butyl‐5‐chloro‐3__H__‐imidazole‐4‐carbaldehyde was transformed into tricyclic heterocycles by substituting the chlorine atom by an unsaturated thiolate or alkoxide and then converting aldehyde function into 1,3‐dipole. Chloramine‐T was used as an efficient reagent for the generation of 1,3‐dipoles, which resulted the formation of fused ring heterocycles via intramolecular 1,3‐dipolar cycloaddition reaction. The method is very useful for the construction of many biologically active fused heterocycles. J. Heterocyclic Chem., (2010).

📜 SIMILAR VOLUMES

ChemInform Abstract: 2-Butyl-5-chloro-3H

ChemInform Abstract: 2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde as a New Synthon for the Synthesis of Fused Ring Heterocycles via Intramolecular 1,3-Dipolar Cycloaddition Reactions.

✍ S. L. Gaonkar; K. M. Lokanatha Rai 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

ChemInform Abstract: Poly(ethylene glyco

ChemInform Abstract: Poly(ethylene glycol) (PEG-400) as an Alternative Reaction Solvent for the Synthesis of Some New 1-(4-(4′-Chlorophenyl)-2-thiazolyl)-3-aryl-5- (2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazolines and Their in vitro Antimicrobial Evaluation.

✍ Bhaskar S. Dawane; Shankaraiah G. Konda; Gajanan G. Mandawad; Baseer M. Shaikh 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 59 KB 👁 2 views

An Unusual Addition and Ring-Closure Rea

An Unusual Addition and Ring-Closure Reaction of 1-(2-Bromoethyl)-2,3-dihydro-3-propyl-1,3,2-benzodiazaphosphorin-4 (1H)-one 2-Oxide with Carbon Disulfide for a New and Convenient Synthesis of the Fused Phosphorus Heterocyclic Compound.

✍ Jun-Min Huang; Hui Chen; Ru-Yu Chen 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

Fluorinated Heterocyclic Compounds. An E

Fluorinated Heterocyclic Compounds. An Effective Strategy for the Synthesis of Fluorinated (Z)-Oximes of 3-Perfluoroalkyl-6-phenyl-2H-1,2,4-triazin-5-ones via a Ring-Enlargement Reaction of 3-Benzoyl-5-perfluoroalkyl-1,2,4-oxadiazoles and Hydrazine.

✍ Silvestre Buscemi; Andrea Pace; Antonio Palumbo Piccionello; Gabriella Macaluso; 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 17 KB 👁 2 views