Novel stereospecific dehydration of β-hydroxy-α-amino acids using Martin's sulfurane

✍ Scribed by Fumiaki Yokokawa; Takayuki Shioiri

• Book ID: 104252346
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 478 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02179-2

✦ Synopsis

The stereospecific dehydration of threo-N-acyl-b-hydroxy-a-amino acid derivatives was performed using Martin's sulfurane to give (Z)-a,b-dehydroamino acids, while erythro-N-acyl-b-hydroxy-a-amino acid amides were converted to 4,5-transoxazolines using analogous reaction conditions.