L-threonine aldolase in organic synthesis: Preparation of novel β-hydroxy-α-amino acids
✍ Scribed by Vassil P. Vassilev; Taketo Uchiyama; Tetsuya Kajimoto; Chi-Huey Wong
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 237 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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Kynureninase in Organic Synthesis: Preparation of γ-Hydroxy-α-Lamino Acids. -Kynureninase catalyzes the transaldol reaction between aromatic and propargylic aldehydes and kynurenine (I). The configuration of the newly formed chiral center at the γ-position of the major isomers (III) is determined t
Reported here is an efficient procedure for enantio-and diastereoselective synthesis of pure b-amino acids that display a tert-hydroxyl functionality in the a-position. Key steps include a catalytic asymmetric aldol reaction and a modified Curtius rearrangement to form oxazolidinone intermediates, w