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Novel route to 3(5)-fluoro-1,2,4-triazoles and 8-fluoropurines by displacement of the nitro group

โœ Scribed by Naik, Shambhu R.; Witkowski, Joseph T.; Robins, Roland K.


Book ID
125885138
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
273 KB
Volume
38
Category
Article
ISSN
0022-3263

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A series of 5-fluoroalkylated 1H-1,2,3-triazoles were synthesized in good yield by the regiospecific 1,3-dipolar cycloaddition reaction of (Z)-ethyl 3-fluoroalkyl-3-pyrrolidino-acrylates with aryl or benzyl azides. In the cases of benzyl azides, addition of Na 2 CO 3 was crucial for a high yield of