✦ LIBER ✦

Efficient synthesis of 5-fluoroalkylated 1H-1,2,3-triazoles and application of the bromodifluoromethylated triazole to the synthesis of novel bicyclic gem-difluorinated 1H-pyrano[3,4-d][1,2,3]-triazol-4-one compounds

✍ Scribed by Weimin Peng; Shizheng Zhu

Book ID: 104205321
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 259 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)00621-5

No coin nor oath required. For personal study only.

✦ Synopsis

A series of 5-fluoroalkylated 1H-1,2,3-triazoles were synthesized in good yield by the regiospecific 1,3-dipolar cycloaddition reaction of (Z)-ethyl 3-fluoroalkyl-3-pyrrolidino-acrylates with aryl or benzyl azides. In the cases of benzyl azides, addition of Na 2 CO 3 was crucial for a high yield of the triazoles. Tetrakis(dimethylamino)ethylene (TDAE) promoted reaction of bromodifluoro-methylated triazole with aldehydes affording a new class of b,b-difluoro-b-triazolyl alcohol derivatives, which were lactonized with catalytic amount of p-toluenesulfonic acid in toluene at 80 -908C to give a series of novel bicyclic gem-difluorinated 1H-pyrano [3,4-d][1,2,3]-triazol-4-one compounds in good yield.

📜 SIMILAR VOLUMES

Efficient Synthesis of 5-Fluoroalkylated

Efficient Synthesis of 5-Fluoroalkylated 1H-1,2,3-Triazoles and Application of the Bromodifluoromethylated Triazole to the Synthesis of Novel Bicyclic gem-Difluorinated 1H-Pyrano[3,4-d][1,2,3]-triazol-4-one Compounds.

✍ Weimin Peng; Shizheng Zhu 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 160 KB 👁 1 views

Efficient Synthesis of 5-Fluoroalkylated

Efficient Synthesis of 5-Fluoroalkylated 1H-1,2,3-Triazoles and Application of the Bromodifluoromethylated Triazole to Prepare New gem-Difluorinated Triazole Compounds.

✍ Weimin Peng; Shizheng Zhu 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 136 KB 👁 1 views

1,2,4-Triazoles, II Synthesis of 1,5-dip

1,2,4-Triazoles, II Synthesis of 1,5-diphenyl-3-trifluoromethyl-1H-1,2,4-triazoles

✍ László Czollner; Géza Szilágyi; József Langó; Judit Janáky 📂 Article 📅 1988 🏛 Springer Vienna 🌐 English ⚖ 205 KB

Novel Method for the Synthesis of 1,2,4-

Novel Method for the Synthesis of 1,2,4-Triazoles and 1,2,4-Triazol-3-ones.

✍ Hanen Chouaieb; Mongi Ben Mosbah; Mohamed Kossentini; Mansour Salem 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 96 KB 👁 1 views

Novel Method for the Synthesis of 1,2,4-

Novel Method for the Synthesis of 1,2,4-Triazoles and 1,2,4-Triazol-3-ones

✍ Chouaieb, Hanen; Ben Mosbah, Mongi; Kossentini, Mohamed; Salem, Mansour 📂 Article 📅 2003 🏛 Taylor and Francis Group 🌐 English ⚖ 191 KB

Synthesis of novel 1,3-substituted 1H-[1

Synthesis of novel 1,3-substituted 1H-[1,2,4]-triazole-3-thiol derivatives

✍ Karine A. Eliazyan; Lusya V. Shahbazyan; Vergine A. Pivazyan; Emma A. Ghazaryan; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB 👁 1 views

## By means of regioselective S-alkylation of 1H-1,2,4-triazole-3-thiol (1), a series of S-substituted derivatives 2a-j were synthesized. In certain conditions, the reaction of 2 with arylsulfochlorides, arylisocyanates, and quaternary ammonium salts of azines corresponding compounds were obtained