A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptable pharmacokinetics and microsomal stability
Novel Pyrrolidine Ureas as C−C Chemokine Receptor 1 (CCR1) Antagonists
✍ Scribed by Merritt, J. Robert; Liu, Jinqi; Quadros, Elizabeth; Morris, Michelle L.; Liu, Ruiyan; Zhang, Rui; Jacob, Biji; Postelnek, Jennifer; Hicks, Catherine M.; Chen, Weiqing; Kimble, Earl F.; Rogers, W. Lynn; O’Brien, Linda; White, Nicole; Desai, Hema; Bansal, Shalini; King, George; Ohlmeyer, Michael J.; Appell, Kenneth C.; Webb, Maria L.
- Book ID
- 120077265
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 157 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-2623
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