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Novel Protein PEGylation Chemistry via Glutalaldehyde-Functionalized PEG

✍ Scribed by Ikeda, Yutaka; Katamachi, Jinya; Kawasaki, Hiromichi; Nagasaki, Yukio


Book ID
121336186
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
644 KB
Volume
24
Category
Article
ISSN
1043-1802

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The identification of PEGylation sites is essential in the characterization of PEGylated therapeutic proteins. This report describes a simple and novel method of finding poly(ethylene glycol) (PEG) conjugation sites in PEGylated proteins by using a hetero-functional biotin-PEG-N-hydroxyl succinimide