Novel Prodrug Approach for Tertiary Amin
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Krise, Jeffrey P.; Zygmunt, Jan; Georg, Gunda I.; Stella, Valentino J.
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Article
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1999
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American Chemical Society
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English
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The synthesis and preliminary evaluation of a novel prodrug approach for improving the water solubility of drugs containing a tertiary amine group are reported. The prodrug synthesis involves a nucleophilic substitution reaction between the parent tertiary amine and a novel derivatizing reagent, di-