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Novel Prodrug Approach for Tertiary Amines: Synthesis and Preliminary Evaluation of N -Phosphonooxymethyl Prodrugs

โœ Scribed by Krise, Jeffrey P.; Zygmunt, Jan; Georg, Gunda I.; Stella, Valentino J.


Book ID
120773560
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
139 KB
Volume
42
Category
Article
ISSN
0022-2623

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Novel Prodrug Approach for Tertiary Amin
โœ Krise, Jeffrey P.; Zygmunt, Jan; Georg, Gunda I.; Stella, Valentino J. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 139 KB

The synthesis and preliminary evaluation of a novel prodrug approach for improving the water solubility of drugs containing a tertiary amine group are reported. The prodrug synthesis involves a nucleophilic substitution reaction between the parent tertiary amine and a novel derivatizing reagent, di-