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A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs

โœ Scribed by Jeffrey P. Krise; William N. Charman; Susan A. Charman; Valentino J. Stella


Book ID
109389204
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
97 KB
Volume
88
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


Novel Prodrug Approach for Tertiary Amin
โœ Krise, Jeffrey P.; Zygmunt, Jan; Georg, Gunda I.; Stella, Valentino J. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 139 KB

The synthesis and preliminary evaluation of a novel prodrug approach for improving the water solubility of drugs containing a tertiary amine group are reported. The prodrug synthesis involves a nucleophilic substitution reaction between the parent tertiary amine and a novel derivatizing reagent, di-