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A novel prodrug approach for tertiary amines. 2. Physicochemical and in vitro enzymatic evaluation of selected N-phosphonooxymethyl prodrugs

โœ Scribed by Jeffrey P. Krise; Shinji Narisawa; Valentino J. Stella


Book ID
109389203
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
135 KB
Volume
88
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


Novel Prodrug Approach for Tertiary Amin
โœ Krise, Jeffrey P.; Zygmunt, Jan; Georg, Gunda I.; Stella, Valentino J. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 139 KB

The synthesis and preliminary evaluation of a novel prodrug approach for improving the water solubility of drugs containing a tertiary amine group are reported. The prodrug synthesis involves a nucleophilic substitution reaction between the parent tertiary amine and a novel derivatizing reagent, di-