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Novel oncogene amplifications in tumors from a family with Li–Fraumeni syndrome

✍ Scribed by Juliane Rieber; Marc Remke; Christian Hartmann; Andrey Korshunov; Birgit Burkhardt; Dominik Sturm; Gunhild Mechtersheimer; Andrea Wittmann; Johann Greil; Claudia Blattmann; Olaf Witt; Wolfgang Behnisch; Marc-Eric Halatsch; Berk Orakcioglu; Andreas von Deimling; Peter Lichter; Andreas Kulozik; Stefan Pfister

Book ID
102844613
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
627 KB
Volume
48
Category
Article
ISSN
1045-2257

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Association of germline or somatic TP53
Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed in patients with Li-Fraumeni or Li-Fraumeni-like syndrome
✍ Waka Sugawara; Yasuhito Arai; Fumio Kasai; Yuiko Fujiwara; Masayuki Haruta; Rie 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 700 KB

## Abstract Germline __TP53__ mutations are found in Li‐Fraumeni syndrome (LFS) patients, predisposed to soft tissue sarcoma and other malignancies. The mutations and succeeding genetic events are thought to cause LFS‐associated cancer, whose genetic alterations have rarely been investigated. Here,