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A Li-Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors

✍ Scribed by Marie Trkova; Lenka Foretova; Roman Kodet; Petra Hedvicakova; Zdenek Sedlacek


Book ID
114135600
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
259 KB
Volume
145
Category
Article
ISSN
0165-4608

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Association of germline or somatic TP53
✍ Waka Sugawara; Yasuhito Arai; Fumio Kasai; Yuiko Fujiwara; Masayuki Haruta; Rie πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 700 KB

## Abstract Germline __TP53__ mutations are found in Li‐Fraumeni syndrome (LFS) patients, predisposed to soft tissue sarcoma and other malignancies. The mutations and succeeding genetic events are thought to cause LFS‐associated cancer, whose genetic alterations have rarely been investigated. Here,