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Novel p53 germline mutation in a patient with Li−Fraumeni syndrome

✍ Scribed by S. S. Wong; G. Lozano; C. L. Gaff; R. J. M. Gardner; L. C. Strong; K. Aittomäki; G. J. Lindeman


Book ID
109001316
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
169 KB
Volume
33
Category
Article
ISSN
1444-0903

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Association of germline or somatic TP53
✍ Waka Sugawara; Yasuhito Arai; Fumio Kasai; Yuiko Fujiwara; Masayuki Haruta; Rie 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 700 KB

## Abstract Germline __TP53__ mutations are found in Li‐Fraumeni syndrome (LFS) patients, predisposed to soft tissue sarcoma and other malignancies. The mutations and succeeding genetic events are thought to cause LFS‐associated cancer, whose genetic alterations have rarely been investigated. Here,