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Novel mutants of human tumor necrosis factor with dominant-negative properties

โœ Scribed by L. N. Shingarova; E. F. Boldyreva; S. A. Yakimov; S. V. Guryanova; D. A. Dolgikh; S. A. Nedospasov; M. P. Kirpichnikov


Book ID
110155486
Publisher
Springer
Year
2010
Tongue
English
Weight
230 KB
Volume
75
Category
Article
ISSN
0006-2979

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A novel recombinant tumor necrosis facto
โœ Satoshi Nakamura; Arata Kato; Tsukio Masegi; Masami Fukuoka; Kazuo Kitai; Hiroko ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 500 KB

We prepared a novel recombinant tumor necrosis factor-u (TNF) mutant (mutant 471), in which 7 N-terminal aminoacids were deleted and ProsSer9Asp'0 was replaced by ArgLysArg, and compared its biological activity with that of wild-type recombinant TNF. Mutant 471 had a 7-fold higher anti-tumor activit