We prepared a novel recombinant tumor necrosis factor-u (TNF) mutant (mutant 471), in which 7 N-terminal aminoacids were deleted and ProsSer9Asp'0 was replaced by ArgLysArg, and compared its biological activity with that of wild-type recombinant TNF. Mutant 471 had a 7-fold higher anti-tumor activit
Construction of novel tumor necrosis factor-alpha mutants with reduced toxicity and higher cytotoxicity on human tumor cells
β Scribed by Hui Liu; Fang Lu; Jianjun Chen; Hongyu Ren; Changqing Chen
- Publisher
- Science in China Press (SCP)
- Year
- 2003
- Tongue
- English
- Weight
- 575 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1674-7305
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