✦ LIBER ✦

Novel muteins of human tumor necrosis factor with potent antitumor activity and less lethal toxicity in mice

✍ Scribed by Kensei Kuroda; Keizo Miyata; Hiroshi Shikama; Tomoko Kawagoe; Koji Nishimura; Ken Takeda; Nahoko Sakae; Masanari Kato

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 716 KB
Volume: 63
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910630127

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✦ Synopsis

Eight muteins of recombinant human tumor necrosis factor-a (rhTNF; 'SSSRTP *

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## Abstract The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well e