𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Characterization of a Novel Human Tumor Necrosis Factor-α Mutant with Increased Cytotoxic Activity

✍ Scribed by Masegi, Tsukio ;Kato, Arata ;Kitai, Kazuo ;Fukuoka, Masami ;Ogawa, Hiroko ;Ichikawa, Yataro ;Nakamura, Satoshi ;Watanabe, Naoki ;Niitsu, Yoshiro

Book ID
108581024
Publisher
Wiley (Blackwell Publishing)
Year
1995
Tongue
English
Weight
701 KB
Volume
86
Category
Article
ISSN
0910-5050

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A novel recombinant tumor necrosis facto
A novel recombinant tumor necrosis factor-alpha mutant with increased anti-tumor activity and lower toxicity
✍ Satoshi Nakamura; Arata Kato; Tsukio Masegi; Masami Fukuoka; Kazuo Kitai; Hiroko 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 500 KB

We prepared a novel recombinant tumor necrosis factor-u (TNF) mutant (mutant 471), in which 7 N-terminal aminoacids were deleted and ProsSer9Asp'0 was replaced by ArgLysArg, and compared its biological activity with that of wild-type recombinant TNF. Mutant 471 had a 7-fold higher anti-tumor activit