𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel inhibitors of 5α-reductase

✍ Scribed by Machetti, Fabrizio; Guarna, Antonio

Book ID
120492484
Publisher
Informa plc
Year
2002
Tongue
English
Weight
208 KB
Volume
12
Category
Article
ISSN
1354-3776

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

5α-reductase inhibitors/finasteride
5α-reductase inhibitors/finasteride
✍ Stoner, Elizabeth 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

Benign prostatic hyperplasia (BPH) is a disease diagnosed by the presence of prostatic enlargement and lower-tract urinary obstruction. Finasteride (Proscar@), is a potent and specific inhibitor of 5a-reductase, which inhibits the conversion of testosterone (T) to dihydrotestosterone (DHT) an import

Steroidal nitrone inhibitors of 5α-reduc
Steroidal nitrone inhibitors of 5α-reductase
✍ Andrea J Robinson; Indawati DeLucca; Spencer Drummond; George A Boswell 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 106 KB

This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i