✦ LIBER ✦

Molecular Modelling of 5α-Reductase Inhibitors

✍ Scribed by Sabbir Ahmed

Book ID: 118110020
Publisher: Pharmaceutical Press
Year: 1996
Tongue: English
Weight: 218 KB
Volume: 2
Category: Article
ISSN: 2042-7158
DOI: 10.1111/j.2042-7158.1996.tb00605.x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

19-Nor-10-azasteroids, a New Class of St

19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. 2. 1 X-ray Structure, Molecular Modeling, Conformational Analysis of 19-Nor-10-azasteroids and Comparison with 4-Azasteroids and 6-Azasteroids

✍ Guarna, Antonio; Occhiato, Ernesto G.; Machetti, Fabrizio; Marrucci, Alessandro; 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 348 KB

ChemInform Abstract: 19-Nor-10-azasteroi

ChemInform Abstract: 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. Part 2. X-Ray Structure, Molecular Modeling, Conformational Analysis of 19-Nor-10-azasteroids and Comparison with 4-Azasteroids and 6-Azasteroids.

✍ A. GUARNA; E. G. OCCHIATO; F. MACHETTI; A. MARRUCCI; G. DANZA; M. SERIO; P. PAOL 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Novel inhibitors of 5α-reductase

✍ Machetti, Fabrizio; Guarna, Antonio 📂 Article 📅 2002 🏛 Informa plc 🌐 English ⚖ 208 KB

5α-Reductase Inhibitors, Chemical and Cl

5α-Reductase Inhibitors, Chemical and Clinical Models

✍ Antonio Guarna; ErnestoG Occhiato; Giovanna Danza; Antonio Conti; Mario Serio 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 224 KB

5α-reductase inhibitors/finasteride

✍ Stoner, Elizabeth 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

Benign prostatic hyperplasia (BPH) is a disease diagnosed by the presence of prostatic enlargement and lower-tract urinary obstruction. Finasteride (Proscar@), is a potent and specific inhibitor of 5a-reductase, which inhibits the conversion of testosterone (T) to dihydrotestosterone (DHT) an import

Steroidal nitrone inhibitors of 5α-reduc

Steroidal nitrone inhibitors of 5α-reductase

✍ Andrea J Robinson; Indawati DeLucca; Spencer Drummond; George A Boswell 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 106 KB

This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i