𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Benefits of long-term α-blockers + 5-α-reductase inhibitors

Book ID
120849424
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2007
Weight
121 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i