๐”– Bobbio Scriptorium
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Novel frameworks as a source of high-affinity ligands

โœ Scribed by Robert C Ladner; Arthur C Ley

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
309 KB
Volume
12
Category
Article
ISSN
0958-1669

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โœฆ Synopsis

The past year has seen further maturation of the techniques used to display populations of proteins and peptides and to select members with desired properties. Many protein domains have now been displayed on genetic packages, diverse populations have been made, and binders with specific useful properties have been selected. Affinity maturation has been demonstrated so that binding in the low nanomolar to subnanomolar range by non-antibodies is now achievable.

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