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Novel, efficient total synthesis of natural 20(S)-camptothecin

✍ Scribed by Tang, Chao-Jun; Babjak, Matej; Anderson, Regan J.; Greene, Andrew E.; Kanazawa, Alice


Book ID
111909160
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
129 KB
Volume
4
Category
Article
ISSN
1477-0520

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πŸ“œ SIMILAR VOLUMES


Total synthesis of natural 20(S)-camptot
✍ Corey, E. J.; Crouse, Dennis N.; Anderson, Jerome E. πŸ“‚ Article πŸ“… 1975 πŸ› American Chemical Society 🌐 English βš– 295 KB
Synthetic Studies on Camptothecins. Part
✍ Li-Peng Zhang; Yong Bao; Yun-Yan Kuang; Fen-Er Chen πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 German βš– 148 KB

## Abstract A six‐step asymmetric total synthesis of (20__S__)‐camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Ni‐catalyzed hydrogenation of 3‐cyanopyridone **6** to 3‐formylpyridone **7**

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✍ Allan W. Nicholas; Mansukh C. Wani; Monroe E. Wall; John A. Kepler; George F. Ta πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 474 KB

## Abstract The synthesis is given for three ring A tritiated camptothecin (CPT) analogs as biological probes in the study of the parent compounds which are of current widespread interest as potent anticancer agents. The strategy of catalytic tritolysis of aryl halide bonds was employed, and thus t