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Novel distribution of sodium-dependent [3H]naloxone binding sites in rat brain

โœ Scribed by L.J. Sim; L. Porrino; S.R. Childers

Book ID
119118675
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
164 KB
Volume
54
Category
Article
ISSN
0167-0115

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Anatomical distribution of sodium-depend
Anatomical distribution of sodium-dependent [3H]naloxone binding sites in rat brain
โœ Laura J. Sim-Selley; Ruoyu Xiao; Steven R. Childers ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 236 KB ๐Ÿ‘ 2 views

The sulfhydryl alkylating reagent N-ethylmaleimide (NEM) blocks opioid receptor binding and receptor/G-protein coupling. Sodium partially restores [ 3 H]naloxone binding after inhibition by NEM to reveal sodium-dependent [ 3 H]naloxone sites, defined as binding in the presence of 50-100 mM NaCl afte