Anatomical distribution of sodium-depend
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Laura J. Sim-Selley; Ruoyu Xiao; Steven R. Childers
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Article
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2000
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John Wiley and Sons
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English
β 236 KB
π 2 views
The sulfhydryl alkylating reagent N-ethylmaleimide (NEM) blocks opioid receptor binding and receptor/G-protein coupling. Sodium partially restores [ 3 H]naloxone binding after inhibition by NEM to reveal sodium-dependent [ 3 H]naloxone sites, defined as binding in the presence of 50-100 mM NaCl afte