Novel, diastereoselective synthesis of 3-amino-1-alkanols

✍ Scribed by Oszbach, György ;Neszmélyi, András

• Book ID: 102366208
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 151 KB
• Volume: 1990
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.199019900138

✦ Synopsis

Abstract

Benzaldehyde adds to 1‐pyrrolidinylcyclohexene under mild conditions giving the amino ketone 3a. The unstable ketone was reduced to the epimeric alcohols 4 and 5, the stereochemistry of which was determined by 2D‐NMR correlation spectroscopy.