Novel Heterocyclic Enediynes. Molecular Design, Chemical Synthesis and DNA Cleavage. -Novel 10-membered oxa-or azaenediynes such as (IV) and (IX) are prepared in short procedures from the known diynes (I) and (V). The azadiynes show effective DNA cleavage under both weakly basic and acidic conditio
✦ LIBER ✦
Novel designed enediynes: Molecular design, chemical synthesis, mode of cycloaromatization and guanine-specific DNA cleavage
✍ Scribed by Kazunobu Toshima; Kazumi Ohta; Takaaki Kano; Takatsugu Nakamura; Masaya Nakata; Mitsuhiro Kinoshita; Shuichi Matsumura
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 776 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0968-0896
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