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ChemInform Abstract: Novel Heterocyclic Enediynes. Molecular Design, Chemical Synthesis and DNA Cleavage.

✍ Scribed by K. TOSHIMA; K. OHISHI; M. TOMISHIMA; S. MATSUMURA


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


Novel Heterocyclic Enediynes. Molecular Design, Chemical Synthesis and DNA Cleavage.

-Novel 10-membered oxa-or azaenediynes such as (IV) and (IX) are prepared in short procedures from the known diynes (I) and (V). The azadiynes show effective DNA cleavage under both weakly basic and acidic conditions. -(TOSHIMA, K.;


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