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ChemInform Abstract: Molecular Design, Chemical Synthesis and Biological Studies of Novel Enediynes Related to Dynemicin A.

✍ Scribed by M.-J. WU; C.-F. LIN; H.-T. CHEN; T.-H. DUH; S.-S. WANG; S.-C. HSU

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable via the β€œReferences” option.

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Novel Heterocyclic Enediynes. Molecular Design, Chemical Synthesis and DNA Cleavage. -Novel 10-membered oxa-or azaenediynes such as (IV) and (IX) are prepared in short procedures from the known diynes (I) and (V). The azadiynes show effective DNA cleavage under both weakly basic and acidic conditio