Novel derivatives at the C21 position of the FK-506 macrocycle
β Scribed by Helen M. Organ; Mark A. Holmes; Judith M. Pisano; Mary Jo Staruch; Matthew J. Wyvratt; Francis J. Dumont; Peter J. Sinclair
- Book ID
- 108477150
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 366 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
I-Substituted te.mcycm. otiho&bmam' meS, ticatalyzed azide rearrangements. 7(or 9)-azimyclines Abstract llwC-8 funcdooalizatiooof te~clinederivatives via acid-catalyzed reatIangemf%It Of 7(or 9)azieyclines is c%zscribed. These ccmpomaaretbefifsttobepreparedfmulanin~ttehacyclincnucleus.
A novel chemical modification was achieved at the 5-position of 2%,3%-O-isopropylideneuridine (6) in a one-pot procedure and a remarkable effect of the base on the progress of the reaction was found.