Novel chiral phosphine–oxazinane ligands in palladium-catalyzed asymmetric allylic alkylation

✍ Scribed by Takashi Mino; Sosuke Hata; Kouji Ohtaka; Masami Sakamoto; Tsutomu Fujita

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 81 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00860-7

✦ Synopsis

Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (8a) with a dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of novel chiral phosphine-oxazinane ligands such as 5b in good yields with good enantioselectivities (up to 95% ee).