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Novel Bis- and Tris-1,2,4-trioxanes: Synthesis and Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii in Swiss Mice(1)

✍ Scribed by Singh, Chandan; Verma, Ved Prakash; Naikade, Niraj Krishna; Singh, Ajit Shankar; Hassam, Mohammad; Puri, Sunil K.


Book ID
120475344
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
290 KB
Volume
51
Category
Article
ISSN
0022-2623

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6-(4β€²-Aryloxy-phenyl)vinyl-1,2,4-trioxan
✍ Chandan Singh; Ved Prakash Verma; Niraj Krishna Naikade; Ajit Shankar Singh; Moh πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 428 KB

A new series of 6-(4 0 -aryloxy-phenyl)vinyl-1,2,4-trioxanes 10a-d, 11a-d, and 12a-d have been synthesized and evaluated for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. Trioxanes 10b and 10c, the two most active compounds of the series, prov