✦ LIBER ✦
6-(4′-Aryloxy-phenyl)vinyl-1,2,4-trioxanes: A new series of orally active peroxides effective against multidrug-resistant Plasmodium yoelii in Swiss mice
✍ Scribed by Chandan Singh; Ved Prakash Verma; Niraj Krishna Naikade; Ajit Shankar Singh; Mohammad Hassam; Sunil. K. Puri
- Book ID
- 104004525
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 428 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
✦ Synopsis
A new series of 6-(4 0 -aryloxy-phenyl)vinyl-1,2,4-trioxanes 10a-d, 11a-d, and 12a-d have been synthesized and evaluated for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. Trioxanes 10b and 10c, the two most active compounds of the series, provided 100% protection to the infected mice at 48 mg/kg  4 days. Clinically useful drug b-arteether provided 100% and 20% protection at 48 mg/kg  4 days and 24 mg/kg  4 days, respectively, in this model.