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Novel Bioreducible Poly(amido amine)s for Highly Efficient Gene Delivery

✍ Scribed by Lin, Chao; Zhong, Zhiyuan; Lok, Martin C.; Jiang, Xulin; Hennink, Wim E.; Feijen, Jan; Engbersen, Johan F. J.

Book ID: 118135752
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 411 KB
Volume: 18
Category: Article
ISSN: 1043-1802
DOI: 10.1021/bc060200l

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## Abstract Three poly(amidoamine)s with pendant primary amines were synthesized by Michael polyaddition of a diamine to __N,N‐__methylenebis(acrylamide). The poly(amidoamine)s with primary and tertiary amines possess a high buffer capacity between pH = 5 and 7, which facilitates the escape of poly