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Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery

✍ Scribed by Chao Lin; Cees-Jan Blaauboer; Miguel Mateos Timoneda; Martin C. Lok; Mies van Steenbergen; Wim E. Hennink; Zhiyuan Zhong; Jan Feijen; Johan F.J. Engbersen


Book ID
113691683
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
995 KB
Volume
126
Category
Article
ISSN
0168-3659

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Poly(amido amine)s as Gene Delivery Vect
✍ Miguel A. Mateos-Timoneda; Martin C. Lok; Wim E. Hennink; Jan Feijen; Johan F. J 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB

## Abstract To evaluate the effect of quaternary nicotinamide pendant groups on gene delivery properties, a series of poly(amido amine) (co)polymers were synthesized by Michael addition polymerization of N, N′‐cystaminebisacrylamide with variable ratios of 1‐(4‐aminobutyl)‐3‐carbamoylpyridinium (Ni